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Probl Endokrinol (Mosk) ; 68(5): 14-23, 2022 Jul 20.
Article Dans Russe | MEDLINE | ID: covidwho-2203930

Résumé

A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread around the world since was first scientifically described in December 2019. At present approximately 400 million people have suffered from the disease, almost 6 million people have died.SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and the serine protease TMPRSS2 for S protein priming. ACE2 and TMPRSS2 are expressed in several endocrine glands, including the pituitary, pancreas, thyroid, ovaries, and testes. Thus, the endocrine glands may be a direct target for SARS-CoV-2. The main risk factors for severity of the COVID-19 are obesity, arterial hypertension, diabetes mellitus (DM), vertebral fractures, which potentially predisposes patients to a severe course of COVID-19.In this review, we present current data on the course of COVID-19 in patients with hypothalamic-pituitary diseases, and also discuss treatment for endocrinopathies during to COVID-19.


Sujets)
COVID-19 , Maladies de l'hypophyse , Humains , Angiotensin-converting enzyme 2 , COVID-19/complications , SARS-CoV-2 , Peptidyl-Dipeptidase A/métabolisme
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